Methanol → 4-Fluoro-2-(morpholine-4-sulfonyl)-phenol

HRID 1971835

반응식

HRID 1971835 반응식
[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:17]C)=[C:6]([S:8]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)(=[O:10])=[O:9])[CH:7]=1.BrB(Br)Br.CO>C(Cl)Cl>[F:1][C:2]1[CH:3]=[CH:4][C:5]([OH:17])=[C:6]([S:8]([N:11]2[CH2:12][CH2:13][O:14][CH2:15][CH2:16]2)(=[O:9])=[O:10])[CH:7]=1

참가 물질

5

반응물 3

HCID 887MethanolHCID 25134Boron tribromideHCID 8499944-(5-Fluoro-2-methoxy-benzenesulfonyl)-morpholine

생성물 1

HCID 581269904-Fluoro-2-(morpholine-4-sulfonyl)-phenol수율 90.8%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a solution of 4-(5-fluoro-2-methoxyphenylsulfonyl)morpholine (0.5 g 1.8 mmol) in CH2Cl2 (10 ml) was added dropwise a solution of tribromoborane (0.593 mg 2.36 mmol) in CH2Cl2 (20 ml) at 0° C. The mixture was stirred at room temperature for 1 h, after which methanol (10 ml) was added to quench the reaction. The solvent was evaporated under reduced pressure and ethyl acetate (30 ml) was added, washed with water and then brine, dried and concentrated into dryness to give the product (427 mg, 90% yield).

후처리

  1. customto quench
  2. customthe reaction
  3. customThe solvent was evaporated under reduced pressure and ethyl acetate (30 ml)
  4. additionwas added
  5. washwashed with water
  6. dry with materialbrine, dried
  7. concentrationconcentrated into dryness

출처 및 근거

ORD 기록
ord-ff47d3c2911042d6b8247f41505c199f
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08431581B2

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