[N:1]1([CH2:7][C:8]2[N:16]3[C:11]([C:12]([NH2:17])=[N:13][CH:14]=[N:15]3)=[CH:10][CH:9]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.C(N(CC)CC)C.C(Cl)Cl.[C:28](OC([O-])=O)([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29]>C1COCC1>[NH2:17][C:12]1[C:11]2=[CH:10][CH:9]=[C:8]([CH2:7][N:1]3[CH2:6][CH2:5][N:4]([C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[CH2:3][CH2:2]3)[N:16]2[N:15]=[CH:14][N:13]=1To a cooled (0° C.) solution of 7-(piperazin-1-ylmethyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (0.85 g, 3.66 mmol) and triethylamine (0.56 mL, 4.03 mmol) in THF (8.5 mL)/DCM (8.5 mL) was added iii-tert-butyl dicarbonate (0.88 g, 4.03 mmol) and the mixture was allowed to warm to rt and further stirred for 18 h and concentrated. The residue was taken up in ethyl acetate, washed with water and dried over Na2SO4 and concentrated (used in the next step without further purification). LC-MS [M+H]+=332.8, RT=1.17 min
불러오는 중…
