Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hexamethylenetetramine → Nordiazepam
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hexamethylenetetramine | HCID 4101 | — |
| 반응물 | Ammonium Hydroxide | HCID 14923 | — |
| 반응물 | 5-Chloro-2-(chloroacetamido)benzophenone | HCID 77635 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Nordiazepam | HCID 2997 | 326.5% |
반응 단계
A mixture of ethanol (1100 mls), hexamethylenetetramine (35 g., 0.25 mol), 26% ammonium hydroxide (58 ml), and 2-chloroacetamido-5-chlorobenzophenone (308.2 g., 1.0 mol) were permitted to react as described in Example 11 except that the reflux period was increased from 5 to 7 hours. The reaction product, 7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one (221 g.) isolated in a manner identical with Example 11, was obtained in 81.6% yield, melting point 208.5° to 209° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US03996209 |
| 출처 데이터셋 | uspto-grants-1976_12 |
| ORD ID | ord-5a34f354b93c4f65965e08277bea0f7c |
| 출처 메모 | uspto-grants-1976_12 |