1-(2-Propynyl)piperazine → HCID 21492752, 화합물

반응식

Cl[CH:2]1[C:8]2[CH:9]=[C:10]([F:13])[CH:11]=[CH:12][C:7]=2[S:6][C:5]2[CH:14]=[C:15]([CH3:18])[CH:16]=[CH:17][C:4]=2[CH2:3]1.[CH2:19]([N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1)[C:20]#[CH:21]>>[CH3:18][C:15]1[CH:16]=[CH:17][C:4]2[CH2:3][CH:2]([N:25]3[CH2:26][CH2:27][N:22]([CH2:19][C:20]#[CH:21])[CH2:23][CH2:24]3)[C:8]3[CH:9]=[C:10]([F:13])[CH:11]=[CH:12][C:7]=3[S:6][C:5]=2[CH:14]=1

참가 물질

반응물 2

HCID 146273691-(2-Propynyl)piperazine

HCID 2141615710-Chloro-8-fluoro-10,11-dihydro-3-methyldibenzo[b,f]thiepin

생성물 1

HCID 21492752HCID 21492752, 화합물

실험 절차

In a manner analogous to that described in Example 1, from 10-chloro-10,11-dihydro-3-methyl-8-fluoro-dibenzo[b,f]thiepin and N-(2-propynyl)-piperazine there is obtained 1-[10,11-dihydro-3-methyl-8-fluoro-dibenzo[b,f]thiepin-10-yl]-4-(2-propynyl)-piperazine, the dimethanesulfonate of which melts at 168°-174° C.

출처 및 근거

ORD 기록: ord-53e152fb228b4aedaa27fb26c2c427e9
출처 데이터셋: uspto-grants-1976_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US03996229

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