Ethanol → 1-(2,2,2-Trifluoroethoxy)-2-Naphthoic Acid
반응식
[F:1][C:2]([F:20])([F:19])[CH2:3][O:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:8]=[CH:7][C:6]=1[C:15]([O:17]C)=[O:16].[OH-].[K+].C(O)C>O>[F:1][C:2]([F:19])([F:20])[CH2:3][O:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:8]=[CH:7][C:6]=1[C:15]([OH:17])=[O:16]참가 물질
5
실험 절차
A mixture of 10 g. (35 mmoles) of methyl 1-(2,2,2-trifluoroethoxy)-2-naphthoate, 2.9 g., (42 mmoles) of potassium hydroxide, 50 ml. of ethanol and 40 ml. of water is refluxed for one hour, chilled and acidified. The fluffy precipitate is collected, water washed, and air-dried. It is purified by recrystallization first from chloroform and then from aqueous alcohol, m.p. 171.5°-172° C.
후처리
- additionA mixture of 10 g
- temperaturechilled
- customThe fluffy precipitate is collected
- washwater washed
- customair-dried
- customIt is purified by recrystallization first from chloroform
출처 및 근거
- ORD 기록
- ord-7aeb48dd48134ebea64d7748f1e929a7
- 출처 데이터셋
- uspto-grants-1976_12
- 특허 번호
- US03996280
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