4-(Chloromethyl)-2-nitroanisole → N,N-dimethyl-N-(3-nitro-4-methoxybenzyl)-N-2-formamidoethylammonium chloride

HRID 1973212노트

반응식

HRID 1973212 반응식
[CH3:1][N:2]([CH3:8])[CH2:3][CH2:4][NH:5][CH:6]=[O:7].[CH3:9][O:10][C:11]1[CH:18]=[CH:17][C:14]([CH2:15][Cl:16])=[CH:13][C:12]=1[N+:19]([O-:21])=[O:20]>O>[Cl-:16].[CH3:1][N+:2]([CH3:8])([CH2:15][C:14]1[CH:17]=[CH:18][C:11]([O:10][CH3:9])=[C:12]([N+:19]([O-:21])=[O:20])[CH:13]=1)[CH2:3][CH2:4][NH:5][CH:6]=[O:7]

참가 물질

4

반응물 2

HCID 807854-(Chloromethyl)-2-nitroanisoleHCID 245580N-(2-(Dimethylamino)ethyl)formamide

생성물 1

HCID 86733012N,N-dimethyl-N-(3-nitro-4-methoxybenzyl)-N-2-formamidoethylammonium chloride

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

A stirred solution of 24.6 parts of N-(2-dimethylaminoethyl)formamide and 30 parts of water was heated to 60° and over a period of one hour there was added 40.3 parts of 4-methoxy-3-nitrobenzylchloride. Heating between 60° and 65° C. was continued for three and one-half hours at which time the pH of the mixture stabilized above 7.0. To the cooled mixture was added 20 parts of water and the resulting mixture was clarified by filtration. An aqueous solution of N,N-dimethyl-N-(3-nitro-4-methoxybenzyl)-N-2-formamidoethylammonium chloride was obtained. This solution was used directly for reduction of the nitro group.

후처리

  1. temperatureHeating between 60° and 65° C.
  2. filtrationthe resulting mixture was clarified by filtration

출처 및 근거

ORD 기록
ord-883c42ba07484e33beda22de1b663f8e
출처 데이터셋
uspto-grants-1976_12
특허 번호
US03996282

반응 노트

불러오는 중…