Sodium Carbonate → HCID 21491289, 화합물

HRID 1973380노트

반응식

HRID 1973380 반응식
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([F:13])[CH:11]=2)[N:6]=[C:5]([C:14]([O:16]CC)=[O:15])[C:4]1=[O:19])[CH3:2].C(=O)([O-])[O-].[Na+].[Na+]>CO.O>[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([F:13])[CH:11]=2)[N:6]=[C:5]([C:14]([OH:16])=[O:15])[C:4]1=[O:19])[CH3:2]

참가 물질

5

반응물 2

HCID 10340Sodium CarbonateHCID 867342554-Ethyl-6-fluoro-3,4-dihydro-3-oxo-2-quinoxalinecarboxylic acid, ethyl ester

생성물 1

HCID 21491289HCID 21491289, 화합물

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

4-Ethyl-6-fluoro-3,4-dihydro-3-oxo-2-quinoxalinecarboxylic acid, ethyl ester (8 g) and sodium carbonate (0.25 g) in methanol (20 ml) and water (10 ml) were heated under reflux for 2 hours. The methanol was distilled off and the aqueous solution was acidified with hydrochloric acid and the solid was collected. It had m.p. 162.5°-164° (39%).

후처리

  1. temperatureunder reflux for 2 hours
  2. distillationThe methanol was distilled off
  3. customthe solid was collected

출처 및 근거

ORD 기록
ord-3f662c70f4384580922093e7c61c580b
출처 데이터셋
uspto-grants-1976_12
특허 번호
US03997535

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