Nitric Acid → Diethyl hydroxy(propan-2-yl)propanedioate

HRID 1973500노트

반응식

HRID 1973500 반응식
[N+]([O-])(O)=[O:2].[CH2:5]([O:7][C:8](=[O:18])[CH:9]([CH:15]([CH3:17])[CH3:16])[C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH3:6]>>[CH2:5]([O:7][C:8](=[O:18])[C:9]([CH:15]([CH3:16])[CH3:17])([C:10]([O:12][CH2:13][CH3:14])=[O:11])[OH:2])[CH3:6]

참가 물질

3

반응물 2

HCID 944Nitric AcidHCID 12966Diethyl isopropylmalonate

생성물 1

HCID 292277Diethyl hydroxy(propan-2-yl)propanedioate

실험 절차

400 g (6.3 mols) of 98 % to 100 % nitric acid are placed in a sulphonating flask, and 10 g (0.05 mols) of isopropyl-malonic acid diethyl ester are added dropwise within 15 minutes at room temperature while stirring. The clear solution is allowed to stand at room temperature for 48 hours. Most of the nitric acid is then carefully removed by evaporation on a rotary evaporator under a water pump vacuum, the residue is distributed between an aqueous potassium hydrogen carbonate solution and a sufficient amount of methylene chloride and is worked up in the usual manner. The methylene chloride phases are again extracted with a small amount of water, dried over sodium sulphate, and the solvent is carefully removed by evaporation in a vacuum. The resulting crude product is distilled in a high vacuum and yields isopropyl-tartronic acid diethyl ester having a B.P. of 65°-67° (0.05 mm of Hg), nD20 = 1.4289.

후처리

  1. customMost of the nitric acid is then carefully removed by evaporation on a rotary evaporator under a water pump vacuum
  2. extractionThe methylene chloride phases are again extracted with a small amount of water
  3. dry with materialdried over sodium sulphate
  4. customthe solvent is carefully removed by evaporation in a vacuum
  5. distillationThe resulting crude product is distilled in a high vacuum

출처 및 근거

ORD 기록
ord-e41e65256ec2447ba7c5cb5a90095e3e
출처 데이터셋
uspto-grants-1976_12
특허 번호
US03997593

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