Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → Benzophenone hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2-Aminopropanol hydrochloride | HCID 110798 | — |
| 반응물 | N-(2-benzoyl-4-chlorophenyl)-2-bromoacetamide | HCID 122906 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Benzophenone hydrochloride | HCID 19775659 | — |
반응 단계
A mixture of 79.4 g. (225 mmole) of 2-(2-bromoacetamido)-5-chlorobenzophenone, 25 g. of 2-aminopropanol hydrochloride, 95 ml. of triethylamine and 500 ml. of ethanol was stirred overnight at room temperature, and then at reflux for 5 hours. The solution was concentrated under reduced pressure to a residue which was partitioned between ether and water. The organic layer was washed with water, dried and treated with hydrogen chloride to give 18 g. of a colorless solid. Recrystallizations from ethanol-ether gave prisms of 5-chloro-2-[2-hydroxy-2-propylamino)acetimido]-benzophenone, hydrochloride, m.p. 183°-186°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US03997591 |
| 출처 데이터셋 | uspto-grants-1976_12 |
| ORD ID | ord-6996254ade3a4b7ca930a84e796b972c |
| 출처 메모 | uspto-grants-1976_12 |