21-Methyl-5alpha-pregnane-3,11,20-trione → 3alpha-Hydroxy-21-methyl-5alpha-pregnane-11,20-dione

HRID 1973715노트

반응식

HRID 1973715 반응식
[CH3:1][CH2:2][C:3](=[O:25])[C@@H:4]1[C@:21]2([CH3:22])[C@H:7]([C@H:8]3[C@H:18]([C:19](=[O:23])[CH2:20]2)[C@:16]2([CH3:17])[C@H:11]([CH2:12][C:13](=[O:24])[CH2:14][CH2:15]2)[CH2:10][CH2:9]3)[CH2:6][CH2:5]1>O.Cl.Cl.Cl[Ir](Cl)(Cl)Cl>[OH:24][C@@H:13]1[CH2:14][CH2:15][C@@:16]2([CH3:17])[C@@H:11]([CH2:10][CH2:9][C@@H:8]3[C@@H:18]2[C:19](=[O:23])[CH2:20][C@@:21]2([CH3:22])[C@H:7]3[CH2:6][CH2:5][C@@H:4]2[C:3](=[O:25])[CH2:2][CH3:1])[CH2:12]1

참가 물질

3

반응물 1

HCID 13171057521-Methyl-5alpha-pregnane-3,11,20-trione

생성물 1

HCID 867342873alpha-Hydroxy-21-methyl-5alpha-pregnane-11,20-dione

시약·촉매·용매 1

HCID 16211483Tetrachloroiridium--hydrogen chloride--water (1/2/1)촉매

실험 절차

21-Methyl-5α-pregnane-3,11,20-trione (0.4 g.) was added to "stock" chloroiridic acid solution (75 ml.) and the resulting mixture was refluxed for 2 hr. The solution was then cooled and partitioned between water and ether. The organic layer was washed with saturated aqueous sodium bicarbonate, dried (Na2SO4) and evaporated.

후처리

  1. temperaturethe resulting mixture was refluxed for 2 hr
  2. temperatureThe solution was then cooled
  3. custompartitioned between water and ether
  4. washThe organic layer was washed with saturated aqueous sodium bicarbonate
  5. dry with materialdried (Na2SO4)
  6. customevaporated

출처 및 근거

ORD 기록
ord-74f27b354f7046d6a5fd64635496c2cf
출처 데이터셋
uspto-grants-1976_12
특허 번호
US03998829

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