HCID 86734286, 화합물 → 3alpha-Hydroxy-21-methyl-5alpha-pregnane-11,20-dione

HRID 1973720노트

반응식

HRID 1973720 반응식
[OH:1][C@@H:2]1[CH2:22][CH2:21][C@@:20]2([CH3:23])[C@@H:4]([CH2:5][CH2:6][C@@H:7]3[C@@H:19]2[C:18](=[O:24])[CH2:17][C@@:16]2([CH3:25])[C@H:8]3[CH2:9][CH2:10][C@@H:11]2[C:12](=[O:15])[CH:13]=[CH2:14])[CH2:3]1>[Pd].C(OCC)(=O)C>[OH:1][C@@H:2]1[CH2:22][CH2:21][C@@:20]2([CH3:23])[C@@H:4]([CH2:5][CH2:6][C@@H:7]3[C@@H:19]2[C:18](=[O:24])[CH2:17][C@@:16]2([CH3:25])[C@H:8]3[CH2:9][CH2:10][C@@H:11]2[C:12](=[O:15])[CH2:13][CH3:14])[CH2:3]1

참가 물질

4

반응물 1

HCID 86734286HCID 86734286, 화합물

생성물 1

HCID 867342873alpha-Hydroxy-21-methyl-5alpha-pregnane-11,20-dione수율 93.6%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

3α-Hydroxy-21-methylene-5α-pregnane-11,20-dione(850 mg) was hydrogenated over 10% palladium on carbon catalyst (80 mg) in ethyl acetate for 1 hour. The catalyst was filtered off and the solvent removed in vacuo to give title compound (800 mg) as a white solid identical with the material of Example 1.

후처리

  1. filtrationThe catalyst was filtered off
  2. customthe solvent removed in vacuo

출처 및 근거

ORD 기록
ord-be99e8bd0d0b4f3fba08851e7dfb8a4c
출처 데이터셋
uspto-grants-1976_12
특허 번호
US03998829

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