Thionyl Chloride → 2',5-Dichloro-2-(3-(chloromethyl)-5-methyl-4H-1,2,4-triazol-4-yl)benzophenone

반응식

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:24])[C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=1[N:16]1[C:20]([CH3:21])=[N:19][N:18]=[C:17]1[CH2:22]O.S(Cl)([Cl:27])=O>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:24])[C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=1[N:16]1[C:20]([CH3:21])=[N:19][N:18]=[C:17]1[CH2:22][Cl:27]

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 64529502',5-Dichloro-2-(3-hydroxymethyl-5-methyl-4H-1,2,4-triazol-4-yl)benzophenone

생성물 1

HCID 5808932',5-Dichloro-2-(3-(chloromethyl)-5-methyl-4H-1,2,4-triazol-4-yl)benzophenone

실험 절차

In the manner given in Example 6, 2',5-dichloro-2-[3-(hydroxymethyl)-5-methyl-4H-1,2,4-triazol-4-yl]benzophenone is warmed with thionylchloride to give 2',5-dichloro-2-[3-(chloromethyl)-5-methyl-4H-1,2,4-triazol-4-yl]benzophenone of melting point 127°-130° C.

출처 및 근거

ORD 기록: ord-99747c1fec0f49bc9517eca416838a59
출처 데이터셋: uspto-grants-1976_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04000153

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