Trifluoroacetic acid → cis-3-Amino-2-azidomethyl-4-oxoazetidine

HRID 1974184노트

반응식

HRID 1974184 반응식
[N:1]([CH2:4][C@H:5]1[C@@H:8]([NH:9]C(OC(C)(C)C)=O)[C:7](=[O:17])[NH:6]1)=[N+:2]=[N-:3].FC(F)(F)C(O)=O>C(Cl)Cl>[NH2:9][C@H:8]1[C:7](=[O:17])[NH:6][C@H:5]1[CH2:4][N:1]=[N+:2]=[N-:3]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 86734331cis-2-Azidomethyl-3-t-butoxycarbonylamino-4-oxoazetidine

생성물 1

HCID 86734332cis-3-Amino-2-azidomethyl-4-oxoazetidine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

cis-2-Azidomethyl-3-t-butoxycarbonylamino-4-oxoazetidine (ca. 1 g) is dissolved in 2 ml of methylene chloride and the solution is cooled to 0° and treated with 0.5 ml of trifluoroacetic acid for 30 minutes at 0°. The solution is washed with 5% aqueous sodium bicarbonate and extracted with dilute hydrochloric acid. The aqueous phase is neutralized and extracted with ethyl acetate. Evaporation of the solvent gives the title compound.

후처리

  1. temperaturethe solution is cooled to 0°
  2. washThe solution is washed with 5% aqueous sodium bicarbonate
  3. extractionextracted with dilute hydrochloric acid
  4. extractionextracted with ethyl acetate
  5. customEvaporation of the solvent

출처 및 근거

ORD 기록
ord-eecd997b997e4601848a1256f0fb5a89
출처 데이터셋
uspto-grants-1976_12
특허 번호
US04000154

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