Sulfuric Acid → 2-(3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)benzamide

HRID 1974326노트

반응식

HRID 1974326 반응식
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[C:13]2=[N:14][CH:15]=[CH:16][CH:17]=[C:12]2[N:11]=[N:10]1)#[N:2].S(=O)(=O)(O)[OH:19].[OH-].[NH4+]>>[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[C:13]2=[N:14][CH:15]=[CH:16][CH:17]=[C:12]2[N:11]=[N:10]1)(=[O:19])[NH2:2]

참가 물질

4

반응물 3

HCID 1118Sulfuric AcidHCID 14923Ammonium HydroxideHCID 124454992-(3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)benzonitrile

생성물 1

HCID 124455002-(3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)benzamide

실험 절차

The cyano compound (from Example 7) (600 mg.) was dissolved in 8 ml. of concentrated sulfuric acid with ice cooling. After standing at room temperature for 7 hours it was poured onto ice. The cold solution was treated with an excess of ammonium hydroxide. The precipitate was collected, air dried and recrystallized from dimethylformamide and water to give 3-(2-carbamoylphenyl)-3H-1,2,3-triazolo[4,5-b]pyridine, m.p. >340° C.

후처리

  1. additionit was poured onto ice
  2. customThe precipitate was collected
  3. customair dried
  4. customrecrystallized from dimethylformamide and water

출처 및 근거

ORD 기록
ord-9bf51204d5484c06a9628526e635a6d7
출처 데이터셋
uspto-grants-1976_12
특허 번호
US04000286

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