Imidazole → 2-Amino-6-imidazolyl-3-nitropyridine
반응식
[NH2:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4](Cl)[N:3]=1.[NH:12]1[CH:16]=[CH:15][N:14]=[CH:13]1.O>CN(C)C=O>[NH2:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([C:13]2[NH:12][CH:16]=[CH:15][N:14]=2)[N:3]=1참가 물질
5
반응 조건
- 온도
- 120 °C
실험 절차
In 80 ml of N,N-dimethylformamide were dissolved 4.00 g of 2-amino-6-chloro-3-nitropyridine and 15.69 g of imidazole, and the solution was stirred at 120° C. overnight. After spontaneous cooling to room temperature, 100 ml of water was added and the resulting crystals were collected by filtration. The crystals were rinsed with a small amount of water and dried under reduced pressure to provide 3.76 g of 2-amino-6-imidazolyl-3-nitropyridine. Physicochemical properties:
후처리
- temperatureAfter spontaneous cooling to room temperature
- filtrationthe resulting crystals were collected by filtration
- washThe crystals were rinsed with a small amount of water
- customdried under reduced pressure
출처 및 근거
- ORD 기록
- ord-8083c1e4eb534a719866e28c0fed96f7
- 출처 데이터셋
- uspto-grants-1994_02
- 특허 번호
- US05283244
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