Acetic acid, [(4-fluoro-2-nitrophenyl)amino]oxo-, ethyl ester → 7-fluoro-1-hydroxyquinoxaline-2,3-(1H,4H)-dione
반응식
[C:1]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=1[N+:16]([O-:18])=O)([C:3](OCC)=[O:4])=[O:2]>[Pd].CN(C=O)C>[F:15][C:12]1[CH:11]=[C:10]2[C:9]([NH:8][C:1](=[O:2])[C:3](=[O:4])[N:16]2[OH:18])=[CH:14][CH:13]=1참가 물질
4
실험 절차
To a mixture of 5.6 g of 2-ethoxalylamino-5-fluoronitrobenzene and 170 ml of DMF was added 0.3 g of 10% Pd-C, and hydrogenation reaction was carried out at ordinary temperature and pressure. The reaction mixture was then filtered and concentrated under reduced pressure. The resulting residue was recrystallized from ethanol to provide 3.68 g (85%) of 7-fluoro-1-hydroxyquinoxaline-2,3-(1H,4H)-dione
후처리
- additionwas added
- filtrationThe reaction mixture was then filtered
- concentrationconcentrated under reduced pressure
- customThe resulting residue was recrystallized from ethanol
출처 및 근거
- ORD 기록
- ord-068db328e3d749cb93d3bc464b49f557
- 출처 데이터셋
- uspto-grants-1994_02
- 특허 번호
- US05283244
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