Imidazole → 4-Amino-2-(1-imidazolyl)-5-nitrobenzonitrile
반응식
[NH2:1][C:2]1[C:9]([N+:10]([O-:12])=[O:11])=[CH:8][C:5]([C:6]#[N:7])=[C:4](F)[CH:3]=1.[NH:14]1[CH:18]=[CH:17][N:16]=[CH:15]1>CN(C=O)C.O>[NH2:1][C:2]1[C:9]([N+:10]([O-:12])=[O:11])=[CH:8][C:5]([C:6]#[N:7])=[C:4]([N:14]2[CH:18]=[CH:17][N:16]=[CH:15]2)[CH:3]=1참가 물질
5
반응 조건
- 온도
- 100 °C
실험 절차
In 5 ml of DMF were dissolved 1 g of 4-amino-2-fluoro-5-nitrobenzonitrile and 1.1 g of imidazole, and the mixture was stirred at 100° C. for 1 hour. The reaction mixture was then diluted with water and the resulting crystals were recovered by filtration to provide 1.2 g of 4-amino-2-(1-imidazolyl)-5-nitrobenzonitrile. Physicochemical properties:
후처리
- filtrationthe resulting crystals were recovered by filtration
출처 및 근거
- ORD 기록
- ord-e22b3da583c34e09ab26d9a16d00bdb4
- 출처 데이터셋
- uspto-grants-1994_02
- 특허 번호
- US05283244
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