Nitric Acid → 2,3-Dimethyl-5-nitrobenzoic acid

HRID 1974553

반응식

HRID 1974553 반응식
[N+:1]([O-:4])(O)=[O:2].S(=O)(=O)(O)O.[CH3:10][C:11]1[C:19]([CH3:20])=[CH:18][CH:17]=[CH:16][C:12]=1[C:13]([OH:15])=[O:14]>>[CH3:10][C:11]1[C:19]([CH3:20])=[CH:18][C:17]([N+:1]([O-:4])=[O:2])=[CH:16][C:12]=1[C:13]([OH:15])=[O:14]

참가 물질

4

반응물 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 117822,3-Dimethylbenzoic acid

생성물 1

HCID 137581312,3-Dimethyl-5-nitrobenzoic acid

실험 절차

To a mixture of nitric acid (d=1.42:20 ml) and sulfuric acid (d=1.84:20 ml) was added 2,3-dimethyl benzoic acid (6.0 g) at 0° C. After stirring for 3 hours, the mixture was poured into ice water (300 ml). The organic layer was extracted with ethyl acetate (100 ml) and washed with water (100 ml×3). The solution was dried over magnesium sulfate and the solvent was removed in vacuo. The residue was purified by a column of silica gel to give a yellow solid of 2,3-dimethyl-5-nitrobenzoic acid (1.80 g).

후처리

  1. extractionThe organic layer was extracted with ethyl acetate (100 ml)
  2. washwashed with water (100 ml×3)
  3. dry with materialThe solution was dried over magnesium sulfate
  4. customthe solvent was removed in vacuo
  5. customThe residue was purified by a column of silica gel

출처 및 근거

ORD 기록
ord-36076d0bf7d74bbdb5dd471ef7b23b11
출처 데이터셋
uspto-grants-1994_02
특허 번호
US05283251

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