홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Benzyltrimethylammonium hydroxide → trans-6-Cyano-4-(1,2-dihydro-4-fluoro-2-oxopyrid-1-yl)-2,2-dimethylchroman-3-ol

HRID 1974840
노트
인쇄 미리보기

반응식

HRID 1974840 반응식
[C:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[O:9][C:8]([CH3:14])([CH3:13])[CH:7]1[O:15][CH:6]21)#[N:2].[F:16][C:17]1[CH:22]=[CH:21][NH:20][C:19](=[O:23])[CH:18]=1.[OH-].C([N+](C)(C)C)C1C=CC=CC=1>O1CCCC1>[C:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[O:9][C:8]([CH3:14])([CH3:13])[C@@H:7]([OH:15])[C@@H:6]2[N:20]1[CH:21]=[CH:22][C:17]([F:16])=[CH:18][C:19]1=[O:23])#[N:2]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 66854Benzyltrimethylammonium hydroxideHCID 3384594-Fluoropyridin-2(1H)-oneHCID 108673602,2-Dimethyl-3,4-epoxy-6-cyanochroman

생성물 1

HCID 67823918trans-6-Cyano-4-(1,2-dihydro-4-fluoro-2-oxopyrid-1-yl)-2,2-dimethylchroman-3-ol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A mixture containing 460 mg of 6-cyano-2,2-dimethyl-3,4-epoxychromane, 283 mg of 4-fluoropyrid-2-one (PREPARATION III) and 0.05 ml of a methanolic solution containing 35% of benzyltrimethylammonium hydroxide, in 5 ml of tetrahydrofuran, is refluxed for 24 hours. The solvent is concentrated, the residue is taken up in ethyl acetate and the organic phase is then washed with water, dried over sodium sulfate and concentrated under vacuum. The residue obtained is chromatographed on silica using a methylene chloride/methanol mixture (97/3) as the eluent. 200 ml of a white solid are recovered.

후처리

  1. concentrationThe solvent is concentrated
  2. washthe organic phase is then washed with water
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated under vacuum
  5. customThe residue obtained
  6. customis chromatographed on silica using a methylene chloride/methanol mixture (97/3) as the eluent
  7. custom200 ml of a white solid are recovered

출처 및 근거

ORD 기록
ord-1ffec3daa4f24dde9dcea24d74249c9a
출처 데이터셋
uspto-grants-1994_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05284838

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트