1-Benzyl-3-ethylaminomethyl-3-hydroxypyrrolidine → 3-Ethylaminomethyl-3-hydroxypyrrolidine
반응식
C([N:8]1[CH2:12][CH2:11][C:10]([CH2:14][NH:15][CH2:16][CH3:17])([OH:13])[CH2:9]1)C1C=CC=CC=1>CO.[Pd]>[CH2:16]([NH:15][CH2:14][C:10]1([OH:13])[CH2:11][CH2:12][NH:8][CH2:9]1)[CH3:17]참가 물질
4
실험 절차
10 g (42.7 mmol) of 1-benzyl-3-ethylaminomethyl-3-hydroxypyrrolidine in 60 ml of methanol are hydrogenated using 2 g of palladium/active carbon (10%) at 92° C. and 107 bar. The catalyst is filtered off, the filtrate is concentrated and the residue is distilled.
후처리
- customat 92° C.
- filtrationThe catalyst is filtered off
- concentrationthe filtrate is concentrated
- distillationthe residue is distilled
출처 및 근거
- ORD 기록
- ord-8608d8dbac1a4d7683561f0da149e36d
- 출처 데이터셋
- uspto-grants-1994_02
- 특허 번호
- US05284842
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