Methanesulfonamide → HCID 131718332, 화합물

HRID 1974918노트

반응식

HRID 1974918 반응식
[NH:1]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[C@@H:2]([C:14]([OH:16])=[O:15])[CH2:3][C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[CH:6][CH:5]=1.[CH3:24][S:25]([NH2:28])(=[O:27])=[O:26]>C(Cl)Cl>[NH:1]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[C@@H:2]([C:14]([OH:16])=[O:15])[CH2:3][C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[CH:6][CH:5]=1.[CH3:24][S:25]([NH2:28])(=[O:27])=[O:26]

참가 물질

4

반응물 2

HCID 72879MethanesulfonamideHCID 2734502N-(tert-Butoxycarbonyl)-3-naphthalen-1-yl-D-alanine

생성물 1

HCID 131718332HCID 131718332, 화합물수율 96.8%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Boc-D-1-Nal-OH (0.50 g), methanesulfonamide (0.18 g) DMAP (0.23 g), WSCD·HCl (0.37 g) and CH2Cl2 (10 ml) were reacted in a similar manner to that of Preparation 1-1) to give Boc-D-1-Nal-methanesulfonamide (0.63 g).

후처리

  1. customof Preparation 1-1)

출처 및 근거

ORD 기록
ord-588efe80abe640a3a217d3fa3f5d728a
출처 데이터셋
uspto-grants-1994_02
특허 번호
US05284828

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