Ethanol → Benzeneacetic acid, 3,5-dibromo-4-hydroxy-, ethyl ester

HRID 1975257노트

반응식

HRID 1975257 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH2:10][C:11]([OH:13])=[O:12])[CH:5]=[C:6]([Br:9])[C:7]=1[OH:8].S(=O)(=O)(O)O.[CH2:19](O)[CH3:20]>>[Br:1][C:2]1[CH:3]=[C:4]([CH2:10][C:11]([O:13][CH2:19][CH3:20])=[O:12])[CH:5]=[C:6]([Br:9])[C:7]=1[OH:8]

참가 물질

4

반응물 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 3253142-(3,5-dibromo-4-hydroxyphenyl)acetic acid

생성물 1

HCID 318188Benzeneacetic acid, 3,5-dibromo-4-hydroxy-, ethyl ester

실험 절차

3,5-Dibromo-4-hydroxyphenylacetic acid (60 g, 0.19 mol), from Preparation A, was suspended in 1 L of ethanol and 10 mL of concentrated sulfuric acid and heated at reflux overnight. The reaction mixture was cooled, concentrated and the product collected by filtration, washed with water, and dried in a vacuum oven to obtain ethyl 3,5-dibromo-4-hydroxyphenylacetate.

후처리

  1. temperatureat reflux overnight
  2. temperatureThe reaction mixture was cooled
  3. concentrationconcentrated
  4. filtrationthe product collected by filtration
  5. washwashed with water
  6. customdried in a vacuum oven

출처 및 근거

ORD 기록
ord-bddfa451827142e3b0ae96b43ddcd2e1
출처 데이터셋
uspto-grants-1994_02
특허 번호
US05284971

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