HCID 19099699, 화합물 → HCID 86747569, 화합물

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[CH3:1][O:2][P:3]([CH2:7][C:8]([O-:10])=[O:9])([O:5][CH3:6])=[O:4].[K+].Br[CH2:13][N:14]1[C:18]([C:19]([F:22])([F:21])[F:20])=[C:17]([Cl:23])[C:16]([C:24]#[N:25])=[C:15]1[C:26]1[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][CH:27]=1>CN(C)C=O.O>[CH3:1][O:2][P:3]([CH2:7][C:8]([O:10][CH2:13][N:14]1[C:15]([C:26]2[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][CH:27]=2)=[C:16]([C:24]#[N:25])[C:17]([Cl:23])=[C:18]1[C:19]([F:22])([F:20])[F:21])=[O:9])([O:5][CH3:6])=[O:4]

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실험 절차

A solution of potassium (dimethylphosphono)acetate (0.69 g, 4 mmol) in N,N-dimethylformamide is treated with 1-(bromomethyl)-4-chloro-2-(p-chlorophenyl)-5-(trifluoromethyl)pyrrole-3-carbonitrile (0.79 g, 2 mmol), stirred at room temperature for one hour, diluted with water and extracted with ethyl acetate. The combined organic extracts are washed sequentially with water and brine, dried over anhydrous MgSO4 and concentrated in vacuo to obtain a brown oil. The oil is chromatographed using silica gel and a 1:1 hexanes/ethyl acetate mixture to give the title product as a viscous yellow oil (0.41 g) which is identified by 13C and 19FNMR spectral analyses.