Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(Methylamino)benzoic acid → 1-(4-Methylaminobenzoyl)-4-[2-(4-methylmercaptophenyl)ethyl]piperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(Methylamino)benzoic acid | HCID 66345 | — |
| 반응물 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 반응물 | 1-{2-[4-(Methylsulfanyl)phenyl]ethyl}piperazine | HCID 53859945 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-(4-Methylaminobenzoyl)-4-[2-(4-methylmercaptophenyl)ethyl]piperazine | HCID 54117481 | — |
반응 단계
The 1-(4-methylaminobenzoyl)-4-[2-(4-methylmercaptophenyl)ethyl]piperazine is prepared from 1.66 g of 4-methylaminobenzoic acid, 1.95 g of N,N-carbonyldiimidazole and 2.35 g of 1-[2-(4-methylmercaptophenyl)ethyl]piperazine in dimethylformamide at 85°. The base is purified via the hydrochloride (m.p. 185°, decomp.) and melts at 120°-121°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05286728 |
| 출처 데이터셋 | uspto-grants-1994_02 |
| ORD ID | ord-225fc4c915684fd68275fc99b7a4c063 |
| 출처 메모 | uspto-grants-1994_02 |