1-{4-[N-(2-isopropyloxyethyl)-N-methoxycarbonylcarbonylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine hydrochloride → 1-[4-(2-Isopropyloxyethyl)aminobenzoyl]-4-[2-(4-chlorophenyl)ethyl]piperazine

HRID 1975362노트

반응식

HRID 1975362 반응식
Cl.[CH:2]([O:5][CH2:6][CH2:7][N:8]([C:15]1[CH:37]=[CH:36][C:18]([C:19]([N:21]2[CH2:26][CH2:25][N:24]([CH2:27][CH2:28][C:29]3[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][CH:30]=3)[CH2:23][CH2:22]2)=[O:20])=[CH:17][CH:16]=1)C(C(OC)=O)=O)([CH3:4])[CH3:3].[Cl-].COC(=O)C(O)=O>>[CH:2]([O:5][CH2:6][CH2:7][NH:8][C:15]1[CH:37]=[CH:36][C:18]([C:19]([N:21]2[CH2:22][CH2:23][N:24]([CH2:27][CH2:28][C:29]3[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][CH:30]=3)[CH2:25][CH2:26]2)=[O:20])=[CH:17][CH:16]=1)([CH3:4])[CH3:3]

참가 물질

3

반응물 2

HCID 190994461-{4-[N-(2-isopropyloxyethyl)-N-methoxycarbonylcarbonylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine hydrochlorideHCID 86640482Oxalic acid monomethyl ester chloride

생성물 1

HCID 98455471-[4-(2-Isopropyloxyethyl)aminobenzoyl]-4-[2-(4-chlorophenyl)ethyl]piperazine

실험 절차

In a manner analogous to that described in Example 23, 1-{4-[N-(2-isopropyloxyethyl)-N-methoxycarbonylcarbonylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine hydrochloride having a melting point of 152°-154° is obtained from 3 g of 1-{4-[N-(2-isopropyloxyethyl)amino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine by reaction with oxalic acid monomethyl ester chloride.

출처 및 근거

ORD 기록
ord-eaf7edbb8bda49a8becc320063ccf9c7
출처 데이터셋
uspto-grants-1994_02
특허 번호
US05286728

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