Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(2-(4-Fluorophenyl)ethyl)piperazine → 1-{4-[N-(2-isopropyloxyethyl)-N-chloroacetylamino]benzoyl}-4-[2-(4-fluorophenyl)ethyl]piperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(2-(4-Fluorophenyl)ethyl)piperazine | HCID 11254522 | — |
| 반응물 | 4-[N-(2-isopropyloxyethyl)-N-chloroacetylamino]benzoyl chloride | HCID 19099416 | — |
| 생성물 | 1-{4-[N-(2-isopropyloxyethyl)-N-chloroacetylamino]benzoyl}-4-[2-(4-fluorophenyl)ethyl]piperazine | HCID 19099419 | — |
반응 단계
Analogously to Example 55, 1.5 g of 4-[N-(2-isopropyloxyethyl)-N-chloroacetylamino]benzoyl chloride are reacted with 0.9 g of [2-(4-fluorophenyl)ethyl]piperazine, yielding 1-{4-[N-(2-isopropyloxyethyl)-N-chloroacetylamino]benzoyl}-4-[2-(4-fluorophenyl)ethyl]piperazine. The hydrochloride thereof melts at 166°-167°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05286728 |
| 출처 데이터셋 | uspto-grants-1994_02 |
| ORD ID | ord-ee022453f72f46ca9740381ffa49db10 |
| 출처 메모 | uspto-grants-1994_02 |