Ammonia → 5-(2-Hydroxyethyl)pyrrolidin-2-one

반응식

C(O[CH:5]1[CH2:12][CH2:11][O:10][C:8](=[O:9])[CH2:7][CH2:6]1)(=O)C.[NH3:13]>>[OH:10][CH2:11][CH2:12][CH:5]1[NH:13][C:8](=[O:9])[CH2:7][CH2:6]1

참가 물질

반응물 2

HCID 222Ammonia

HCID 117450862-Oxepanone, 5-(acetyloxy)-

생성물 1

HCID 108554765-(2-Hydroxyethyl)pyrrolidin-2-one

실험 절차

22.4 g of 4-acetoxycaprolactone were stirred for 1 hour at 330° C. in an autoclave together with 100 g of 25% strength aqueous ammonia. After cooling and depressurizing the autoclave, the reaction product was concentrated on a rotary evaporator (40° C./30 mbar) and purified by short path distillation. In this case, 10.1 g of 5-hydroxyethylpyrrolidone were obtained (61%, based on the 4-acetoxycaprolactone employed) and identified by NMR spectroscopy.

후처리

temperatureAfter cooling
concentrationthe reaction product was concentrated on a rotary evaporator (40° C./30 mbar)
distillationpurified by short path distillation

출처 및 근거

ORD 기록: ord-681a67c854174aa6978cc40b7d9e9217
출처 데이터셋: uspto-grants-1994_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05286875

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