Ammonia → 5-(2-Hydroxyethyl)pyrrolidin-2-one
반응식
CO[CH:3]1[CH2:10][CH2:9][O:8][C:6](=[O:7])[CH2:5][CH2:4]1.[NH3:11]>>[OH:8][CH2:9][CH2:10][CH:3]1[NH:11][C:6](=[O:7])[CH2:5][CH2:4]1참가 물질
3
실험 절차
30 g of 4-methoxycaprolactone were stirred at 330° C. for 1 hour together with 100 g of 25% strength aqueous ammonia in the same manner as described in Example 4. After cooling and depressurizing the autoclave and working up the reaction mixture by distillation, 9.1 g of 5-hydroxyethylpyrrolidone were obtained (34%, based on the 4-methoxycaprolactone employed) and identified by NMR spectroscopy.
후처리
- temperatureAfter cooling
- distillationworking up the reaction mixture by distillation
출처 및 근거
- ORD 기록
- ord-ba12bb7415234863b543db073f5e611b
- 출처 데이터셋
- uspto-grants-1994_02
- 특허 번호
- US05286875
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