1-(4-Pyridyl)piperazine → HCID 22721857, 화합물

반응식

[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[S:11]([NH:14][CH2:15][CH2:16][CH2:17][C:18]([OH:20])=O)(=[O:13])=[O:12].[N:21]1[CH:26]=[CH:25][C:24]([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)=[CH:23][CH:22]=1>>[N:21]1[CH:26]=[CH:25][C:24]([N:27]2[CH2:28][CH2:29][N:30]([C:18]([CH2:17][CH2:16][CH2:15][NH:14][S:11]([C:2]3[CH:3]=[CH:4][C:5]4[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=4)[CH:1]=3)(=[O:12])=[O:13])=[O:20])[CH2:31][CH2:32]2)=[CH:23][CH:22]=1

참가 물질

반응물 2

HCID 705171-(4-Pyridyl)piperazine

HCID 3627424-(Naphthalene-2-sulfonamido)butanoic acid

생성물 1

HCID 22721857HCID 22721857, 화합물수율 15%

실험 절차

Using an analogous procedure to that described in Example 36, 4-(2-naphthalenesulphonamido)butyric acid was reacted with 1-(4-pyridyl)piperazine to give N-{3-[4-(4-pyridyl)piperazin-1-ylcarbonyl]propyl}naphthalene-2-sulphonamide in 15% yield as a foam;

출처 및 근거

ORD 기록: ord-bea657974edd4ea1b72c6948548c27ac
출처 데이터셋: uspto-grants-2001_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06225309B1

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