Piperazine → 1-(3-Bromobenzenesulfonyl)piperazine

HRID 1976022노트

반응식

[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[Br:7][C:8]1[CH:9]=[C:10]([S:14](Cl)(=[O:16])=[O:15])[CH:11]=[CH:12][CH:13]=1>>[Br:7][C:8]1[CH:9]=[C:10]([S:14]([N:1]2[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)(=[O:16])=[O:15])[CH:11]=[CH:12][CH:13]=1

참가 물질

반응물 2

HCID 4837Piperazine

HCID 17943m-Bromobenzenesulphonyl chloride

생성물 1

HCID 24052531-(3-Bromobenzenesulfonyl)piperazine

실험 절차

Using analogous procedures to those described in the portion of Example 58 which is concerned with the preparation of starting materials, piperazine was reacted with 3-bromophenylsulphonyl chloride to give 1-(3-bromophenylsulphonyl)piperazine which, in turn, was reacted with 3,5-dichlorophenylboronic acid to give 1-(3′,5′-dichlorobiphenyl-3-ylsulphonyl)piperazine in 29% yield;

출처 및 근거

ORD 기록: ord-3b407b2ae1334481872cc7da50229682
출처 데이터셋: uspto-grants-2001_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06225309B1

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