Benzyl Bromide → 2-Benzyloxy-3-bromo-5-trifluoromethylpyridine
반응식
[Br:1][C:2]1[C:3](=[O:12])[NH:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[CH2:13](Br)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>CCCCCC.C(=O)([O-])[O-].[Ag+2]>[CH2:13]([O:12][C:3]1[C:2]([Br:1])=[CH:7][C:6]([C:8]([F:11])([F:10])[F:9])=[CH:5][N:4]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1참가 물질
5
실험 절차
3-Bromo-5-trifluoromethyl-2(1H)-pyridone (6.09 g, 25.2 mmol) and silver carbonate (7.18 g, 26.0 mmol) were suspended in hexane (200 mL) and treated with benzyl bromide (6 mL, 50.3 mmol). The mixture was stirred for 18 hrs, then filtered. The filtrate was concentrated and the residue purified by silica chromatography to give the product as a white solid (7.65 g, 23 mmol, 91% yield).
후처리
- filtrationfiltered
- concentrationThe filtrate was concentrated
- customthe residue purified by silica chromatography
출처 및 근거
- ORD 기록
- ord-33da332533ff41c3a8792822a9d935af
- 출처 데이터셋
- uspto-grants-2001_05
- 특허 번호
- US06225320B1
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