Propylene Oxide → Cis-4-Hydroxy-D-Proline

HRID 1976229노트

반응식

HRID 1976229 반응식
Cl.[OH:2][C@H:3]1[CH2:7][NH:6][C@@H:5]([C:8]([OH:10])=[O:9])[CH2:4]1.C1OC1C>C(O)C>[OH:2][C@H:3]1[CH2:7][NH:6][C@@H:5]([C:8]([OH:10])=[O:9])[CH2:4]1

참가 물질

4

반응물 2

HCID 6378Propylene OxideHCID 12310682(2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid hydrochloride

생성물 1

HCID 440014Cis-4-Hydroxy-D-Proline수율 85.4%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 4.5 g of cis-4-hydroxy-D-proline hydrochloride in 300 ml of ethanol, there was added 13.1 g of propylene oxide at room temperature and then the mixture was heated under refluxing for one hour. After allowing the reaction liquid to cool, the crystals precipitated were filtered off, washed with ethanol and then dried to give 3.0 g (yield 85.4%) of the title compound.

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder refluxing for one hour
  3. customthe reaction liquid
  4. temperatureto cool
  5. customthe crystals precipitated
  6. filtrationwere filtered off
  7. washwashed with ethanol
  8. customdried

출처 및 근거

ORD 기록
ord-3f26763b80a24a19a92ac78a613c5999
출처 데이터셋
uspto-grants-2001_05
특허 번호
US06225306B1

반응 노트

불러오는 중…