HCID 21996968, 화합물 → HCID 21996988, 화합물
반응식
BrC1C=CC(O)=C(C=1)C(C1C=CC(C)=CC=1)=O.[Br:18][C:19]1[CH:20]=[CH:21][C:22]([O:34]C)=[C:23]([CH:33]=1)[C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([CH3:32])[CH:27]=1)=[O:25]>>[Br:18][C:19]1[CH:20]=[CH:21][C:22]([OH:34])=[C:23]([CH:33]=1)[C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([CH3:32])[CH:27]=1)=[O:25]참가 물질
3
실험 절차
Employing the same general procedure as for the preparation 5-bromo-2-hydroxy-4′-methylbenzophenone (Compound K), 533 mg (1.7 mmol) of 5-bromo-2-methoxy-3′-methylbenzophenone (Compound J) was converted into the title compound using 2.6 mL (2.6 mmol) of boron tribromide (1M in dichloromethane) and 15 mL of dichloromethane. Purification by flash chromatography (silica, 10% ethyl acetate in hexane) gave the title compound as a white solid.
출처 및 근거
- ORD 기록
- ord-e0e682dfb3aa442bbeffb9f1fb04c9a9
- 출처 데이터셋
- uspto-grants-2001_05
- 특허 번호
- US06225494B1