Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chlorosuccinimide → 3-Chloro-1H-indole-5-carboxylic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chlorosuccinimide | HCID 31398 | — |
| 반응물 | methyl 1H-indole-5-carboxylate | HCID 2737635 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 3-Chloro-1H-indole-5-carboxylic acid methyl ester | HCID 21998728 | 66.4% |
반응 단계
A solution of methyl 5-indolecarboxylate (501.1 mg, 2.65 mmol) in methanol (15 mL) was treated with N-chlorosuccinimide (425.4 mg, 3.18 mmol), stirred for 18 hours, and concentrated. The concentrate was dissolved into ethyl acetate, and this solution was washed with 1M NaHCO3 (2×), dried (MgSO4), filtered, and concentrated. The concentrate was purified on silica gel with 15% ethyl acetate/hexanes to provide 368.8 mg of the desired product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06228868B1 |
| 출처 데이터셋 | uspto-grants-2001_05 |
| ORD ID | ord-932d88836c234f719928692ef1000938 |
| 출처 메모 | uspto-grants-2001_05 |