Chlorosuccinimide → 1-(5-Bromo-7-chloro-2,3-dihydro-1H-indol-1-yl)ethan-1-one

HRID 1976785노트

반응식

HRID 1976785 반응식
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([Br:13])=[CH:10][CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[Cl:14]N1C(=O)CCC1=O>C(#N)C>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([Br:13])=[CH:10][C:11]=2[Cl:14])[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 31398ChlorosuccinimideHCID 7218471-(5-bromo-2,3-dihydro-1H-indol-1-yl)ethan-1-one

생성물 1

HCID 186292691-(5-Bromo-7-chloro-2,3-dihydro-1H-indol-1-yl)ethan-1-one수율 39.9%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of 1-acetyl-5-bromo-indoline (1.20 g, 5 mmol) and N-chlorosucinimide (0.734 g, 5.5 mmol) in acetonitrile (80 mL) was heated to reflux for 12 hours, cooled to room temperature, and concentrated. The concentrate was purified by flash column chromatography on silica gel to provide 0.548 g of the desired product.

후처리

  1. temperaturewas heated
  2. temperatureto reflux for 12 hours
  3. concentrationconcentrated
  4. customThe concentrate was purified by flash column chromatography on silica gel

출처 및 근거

ORD 기록
ord-e5345672241a408481abc3290b234514
출처 데이터셋
uspto-grants-2001_05
특허 번호
US06228868B1

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