1-Bromodecane → Methyl 1-decylpyrazole-4-carboxylate

HRID 1977272노트

반응식

HRID 1977272 반응식
[NH:1]1[CH:5]=[C:4]([C:6]([O:8][CH3:9])=[O:7])[CH:3]=[N:2]1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26].C(OCC)(=O)C>CN(C)C=O>[CH2:17]([N:1]1[CH:5]=[C:4]([C:6]([O:8][CH3:9])=[O:7])[CH:3]=[N:2]1)[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26]

참가 물질

6

반응물 4

HCID 81731-BromodecaneHCID 8857Ethyl AcetateHCID 11430Potassium CarbonateHCID 9793760Methyl 1H-pyrazole-4-carboxylate

생성물 1

HCID 21997475Methyl 1-decylpyrazole-4-carboxylate수율 91.8%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of methyl pyrazole-4-carboxylate (10 g) in N,N-dimethylformamide (100 ml) was treated with potassium carbonate (10.95 g) and 1-bromodecane (19.31 g) and the mixture was stirred for 16 hours at room temperature. Ethyl acetate was added and the solution was washed with water (6x), dried over magnesium sulfate and the evaporated residue was purified by silica gel chromatography (5:1 hexane-ethyl acetate elution) to give methyl 1-decylpyrazole-4-carboxylate (19.4 g) as a white solid.

후처리

  1. washthe solution was washed with water (6x)
  2. dry with materialdried over magnesium sulfate
  3. customthe evaporated residue was purified by silica gel chromatography (5:1 hexane-ethyl acetate elution)

출처 및 근거

ORD 기록
ord-f0658be6345648c9a1efd316d7a6c00f
출처 데이터셋
uspto-grants-2001_05
특허 번호
US06232290B1

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