Methanol → Methyl 1-(4-aminophenyl)-1H-pyrazole-4-carboxylate

HRID 1977289노트

반응식

HRID 1977289 반응식
[CH3:1][O:2][C:3]([C:5]1[CH:6]=[N:7][N:8]([C:10]2[CH:15]=[CH:14][C:13]([N+:16]([O-])=O)=[CH:12][CH:11]=2)[CH:9]=1)=[O:4].[NH4+].[Cl-].CO>[Fe].O>[CH3:1][O:2][C:3]([C:5]1[CH:6]=[N:7][N:8]([C:10]2[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][CH:11]=2)[CH:9]=1)=[O:4]

참가 물질

6

반응물 3

HCID 887MethanolHCID 25517Ammonium ChlorideHCID 11637370HCID 11637370, 화합물

생성물 1

HCID 57210789Methyl 1-(4-aminophenyl)-1H-pyrazole-4-carboxylate수율 57.6%

시약·촉매·용매 2

HCID 23925Iron촉매HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

A mixture of 1-(4-nitrophenyl)-1H-pyrazol-4-carboxylic acid methyl ester (19.44 g), Fe powder, NH4Cl, methanol and H2O was heated for 30 minutes at 80° C. for 3 hours at 100° C. The reaction mixture was concentrated by evaporation, added into dichloromethane, and was filtered. The filtrate was extracted with water, dried over magnesium sulfate and concentrated by evaporation to give 1-(4-aminophenyl)-1H-pyrazol-4-carboxylic acid methyl ester (9.84 g).

후처리

  1. concentrationThe reaction mixture was concentrated by evaporation
  2. additionadded into dichloromethane
  3. filtrationwas filtered
  4. extractionThe filtrate was extracted with water
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated by evaporation

출처 및 근거

ORD 기록
ord-04e3e676a7a24bac88703dc78c45d21a
출처 데이터셋
uspto-grants-2001_05
특허 번호
US06232290B1

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