Benzhydrylamine → HCID 21998158, 화합물

HRID 1977492노트

반응식

HRID 1977492 반응식
O.[C:2]([OH:6])(=[O:5])[CH:3]=O.[NH2:7][CH:8]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[C:21]1(B(O)O)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>ClCCl>[C:15]1([CH:8]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[NH:7][CH:3]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:2]([OH:6])=[O:5])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

참가 물질

5

반응물 3

HCID 7036BenzhydrylamineHCID 66827Phenylboronic AcidHCID 15620607Glyoxylic acid, monohydrate

생성물 1

HCID 21998158HCID 21998158, 화합물수율 84%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a stirred solution of glyoxylic acid monohydrate (92 mg, 1 mmol) in dichloromethane (7 mL) was added aminodiphenylmethane (183 mg, 1 mmol), followed by phenylboronic acid (122 mg, 1 mmol). After the flask was purged with argon and sealed, the reaction mixture was stirred vigorously at room temperature for 48 h. The resulting precipitate was isolated by filtration, washed with dichloromethane (10 mL) and purified by ion-exchange chromatography (Dowex 50W-X8) to give pure (±)-N-(diphenylmethyl)-α-phenylglycine (266 mg, 84% yield).

후처리

  1. customAfter the flask was purged with argon
  2. customsealed
  3. customThe resulting precipitate was isolated by filtration
  4. washwashed with dichloromethane (10 mL)
  5. custompurified by ion-exchange chromatography (Dowex 50W-X8)

출처 및 근거

ORD 기록
ord-61843cf72a83446ea3c43395d1058ee2
출처 데이터셋
uspto-grants-2001_05
특허 번호
US06232467B1

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