Acetone → (E)-6-Methyl-3-hepten-2-one

HRID 1977522노트

반응식

HRID 1977522 반응식
[CH:1](=O)[CH2:2][CH:3]([CH3:5])[CH3:4].[CH3:7][C:8]([CH3:10])=[O:9]>>[CH3:4][CH:3]([CH3:5])[CH2:2][CH:1]=[CH:7][C:8](=[O:9])[CH3:10]

참가 물질

3

반응물 2

HCID 180AcetoneHCID 115523-Methylbutanal

생성물 1

HCID 137281(E)-6-Methyl-3-hepten-2-one수율 35%

실험 절차

In contrast, the processes comprising subjecting isovaleraldehyde and acetone to aldol condensation in the presence of an aqueous alkali have an advantage that the reaction can be carried out under mild conditions, using inexpensive materials. The process (iv), however, can give 6-methyl-3-hepten-2-one, the aldol condensate, only in a 35 to 40% yield at most. Also, the process (v) mainly forms 6-methyl-4-hydroxyheptan-2-one, and requires successive dehydration reaction in order to obtain the yield of the 6-methyl-3-hepten-2-one. In addition, the yield of the 6-methyl-3-hepten-2-one thus obtained is 51%, which is not satisfactory. Moreover, the process (v) must use acetone in excess, so it is not industrially advantageous in view of the necessity for recovering the excessive acetone and the volumetric efficiency of reaction.

후처리

  1. customcondensation in the presence of an aqueous alkali
  2. customthat the reaction

출처 및 근거

ORD 기록
ord-7fb56c40ff7c466eafa358bddcf55fad
출처 데이터셋
uspto-grants-2001_05
특허 번호
US06232506B1

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