2,3-Dimethylaniline → 6-Chloro-2,3-dimethylaniline

HRID 1977649

반응식

HRID 1977649 반응식
[Cl:1]N1C(=O)CCC1=O.[CH3:9][C:10]1[C:16]([CH3:17])=[CH:15][CH:14]=[CH:13][C:11]=1[NH2:12]>CN(C=O)C>[CH3:9][C:10]1[C:16]([CH3:17])=[CH:15][CH:14]=[C:13]([Cl:1])[C:11]=1[NH2:12]

참가 물질

4

반응물 2

HCID 68932,3-DimethylanilineHCID 31398Chlorosuccinimide

생성물 1

HCID 219947436-Chloro-2,3-dimethylaniline수율 99%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

used in the preparation of 389 was prepared as follows: N-Chlorosuccinimide (1.00 g; 8.2 mmol) was added to a solution of 2,3-dimethylaniline (1 ml; 8.2 mmol) in 20 ml of DMF in the dark. After stirring 1 hr. in the dark, the reaction mixture was partitioned between EtOAc (100 ml) and water (100 ml). The organic layer was washed with 1N NaOH (100 ml), water (100 ml) and brine (50 ml). Drying (MgSO4) and concentration afforded 1.25 g (99%) of 2,3-dimethyl-6-chloroaniline as a deep red liquid.

후처리

  1. customwas prepared
  2. customin the dark, the reaction mixture was partitioned between EtOAc (100 ml) and water (100 ml)
  3. washThe organic layer was washed with 1N NaOH (100 ml), water (100 ml) and brine (50 ml)
  4. customDrying
  5. concentration(MgSO4) and concentration

출처 및 근거

ORD 기록
ord-b0cb638d6a32473e867ac1465c30ef9d
출처 데이터셋
uspto-grants-2001_05
특허 번호
US06235740B1

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