2-Bromopyridine → 2-methoxy-N-(2-pyridyl)acetanilide

HRID 1977666

반응식

HRID 1977666 반응식
[CH3:1][O:2][CH2:3][C:4]([NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[O:5].Br[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=1>>[CH3:1][O:2][CH2:3][C:4]([N:6]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[O:5]

참가 물질

3

반응물 2

HCID 79732-BromopyridineHCID 2642222-methoxy-N-phenylacetamide

생성물 1

HCID 219935682-methoxy-N-(2-pyridyl)acetanilide수율 58.6%

실험 절차

Using 2-methoxy-acetanilide (5.0 g) and 2-bromopyridine (9.5 g), a reaction was made in the same manner as in 1) of Production Example 14. The subsequent purification by silica gel column chromatography (developing solvent, ethyl acetate: hexane=1:1) produced 2-methoxy-N-(2-pyridyl)acetanilide (4.3 g, crude product) as a yellow oil.

후처리

  1. customThe subsequent purification by silica gel column chromatography (developing solvent, ethyl acetate: hexane=1:1)

출처 및 근거

ORD 기록
ord-162c1cd072634f41b05a44072b02e280
출처 데이터셋
uspto-grants-2001_05
특허 번호
US06235730B1

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