홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Isocyanate → 1-[2-(3-Pyridyl)-thiazol-4-yl carbamoyl]-5-methoxy-6-trifluoromethylindoline

HRID 1977760
노트
인쇄 미리보기

반응식

HRID 1977760 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[S:8][CH:9]=[C:10](C(N=[N+]=[N-])=O)[N:11]=2)[CH:2]=1.[N-:17]=[C:18]=[O:19].[CH3:20][O:21][C:22]1[CH:23]=[C:24]2[C:28](=[CH:29][C:30]=1[C:31]([F:34])([F:33])[F:32])[NH:27][CH2:26][CH2:25]2>C1(C)C=CC=CC=1.ClCCl>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[S:8][CH:9]=[C:10]([NH:17][C:18]([N:27]3[C:28]4[C:24](=[CH:23][C:22]([O:21][CH3:20])=[C:30]([C:31]([F:33])([F:34])[F:32])[CH:29]=4)[CH2:25][CH2:26]3)=[O:19])[N:11]=2)[CH:2]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 105034IsocyanateHCID 112067135-Methoxy-6-(trifluoromethyl)indolineHCID 187718652-(3-Pyridinyl)-4-thiazolylcarbonylazide

생성물 1

HCID 232181211-[2-(3-Pyridyl)-thiazol-4-yl carbamoyl]-5-methoxy-6-trifluoromethylindoline수율 15%

시약·촉매·용매 2

HCID 1140Toluene용매
HCID 6344
Dichloromethane
용매

실험 절차

A solution of acyl azide (D15) (370 mg, 1.6 mmol) in toluene (5 ml) was heated to reflux for 0.25 h. After cooling to room temperature, the solution of the isocyanate was added to a solution of 5-methoxy-6-trifluoromethyl indoline (0.35 g, 1.6 mmol) in dichloromethane (10 ml). Filtration and drying afforded the title compound as a white solid (100 mg, 15%), m.p.>200° C.

후처리

  1. temperatureto reflux for 0.25 h
  2. filtrationFiltration
  3. customdrying

출처 및 근거

ORD 기록
ord-b5b2dd94ef5b4356b1f64868ffd7c2d5
출처 데이터셋
uspto-grants-2001_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06235758B1

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트