HCID 21996512, 화합물 → HCID 54094556, 화합물

HRID 1977986노트

반응식

HRID 1977986 반응식
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][CH2:9]/[C:10]/2=[CH:13]/[C:14]#[N:15])=[CH:5][CH:4]=1.N.C(O)C>C(O)C.[Co]>[NH2:15][CH2:14][CH:13]=[C:10]1[C:11]2[C:6](=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[CH:12]=2)[CH2:7][CH2:8][CH2:9]1

참가 물질

5

반응물 2

HCID 21996512HCID 21996512, 화합물HCID 22020343Ethanol, reaction products with ammonia, distn. residues

생성물 1

HCID 54094556HCID 54094556, 화합물

시약·촉매·용매 2

HCID 104730Cobalt촉매HCID 702Ethanol용매

실험 절차

To a solution of (Z)-(1,2,3,4-tetrahydro-7-methoxy-1-naphthylidene)acetonitrile produced in Reference Example 2 (1.84 g, 9.23 mmol) in ethanol (10 ml) were added a saturated ammonia/ethanol solution (5 ml) and Raney cobalt (ODHT-60, 1.8 g). The mixture was stirred for 3 hours at room temperature under hydrogen atmosphere (about 4 kgf/cm2). The Raney cobalt was filtered off, then the solvent was distilled off to give the above-titled compound (a mixture of isomers) (yield 1.46 g, 78%, oil). This compound was used in the subsequent reaction without further purification.

후처리

  1. filtrationThe Raney cobalt was filtered off
  2. distillationthe solvent was distilled off

출처 및 근거

ORD 기록
ord-a97d3f6edb1546d983aa38868a3e0115
출처 데이터셋
uspto-grants-2001_05
특허 번호
US06235789B1

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