Water → 2-(6-Methoxyindan-1-yl)ethanol

HRID 1977995

반응식

HRID 1977995 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH3:7][O:8][C:9]1[CH:17]=[C:16]2[C:12]([CH2:13][CH2:14][CH:15]2[CH2:18][C:19](OCC)=[O:20])=[CH:11][CH:10]=1.O.S([O-])([O-])(=O)=O.[Mg+2]>C1COCC1.C(OCC)(=O)C>[OH:20][CH2:19][CH2:18][CH:15]1[C:16]2[C:12](=[CH:11][CH:10]=[C:9]([O:8][CH3:7])[CH:17]=2)[CH2:13][CH2:14]1

참가 물질

7

반응물 4

HCID 962WaterHCID 24083Sulfuric acid magnesium salt (1:1)HCID 11064342Ethyl (6-methoxyindan-1-yl)acetateHCID 21226445Aluminium lithium hydride

생성물 1

HCID 109978572-(6-Methoxyindan-1-yl)ethanol수율 93%

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매2회HCID 8857Ethyl Acetate용매

실험 절차

To a suspension of lithium aluminum hydride (1.06 g, 27.9 mmol) in THF (150 ml) was added dropwise, under ice-cooling, a solution of ethyl (6-methoxyindan-1-yl)acetate (6.53 g, 27.9 mmol) in THF (20 ml), and the mixture was stirred for 15 minutes. To the reaction mixture was added water (1 ml), to which were further added ethyl acetate, anhydrous magnesium sulfate and celite. The mixture was subjected to filtration. The filtrate was concentrated under reduced pressure to give 4.96 g (yield 93%) of the above-titled compound as an oily product.

후처리

  1. additionwas added dropwise, under ice-
  2. temperaturecooling
  3. filtrationThe mixture was subjected to filtration
  4. concentrationThe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-5a1a1a3d392c47ab8d0f1ec52d0c4df1
출처 데이터셋
uspto-grants-2001_05
특허 번호
US06235789B1

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