Morpholine → HCID 69944285, 화합물

HRID 1978090노트

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HRID 1978090 반응식
N1CCOCC1.C([O:10][C:11]([C@H:13]([CH2:27][CH:28]([CH3:30])[CH3:29])[C@H:14]([O:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:15]([O:17][CH3:18])=[O:16])=[O:12])C=C>O1CCCC1.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[C:11]([C@H:13]([CH2:27][CH:28]([CH3:30])[CH3:29])[C@H:14]([O:19][CH2:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)[C:15]([O:17][CH3:18])=[O:16])([OH:12])=[O:10]

참가 물질

5

반응물 2

HCID 8083MorpholineHCID 69943797HCID 69943797, 화합물

생성물 1

HCID 69944285HCID 69944285, 화합물수율 121.2%

시약·촉매·용매 2

HCID 178418397HCID 178418397, 화합물촉매HCID 8028Tetrahydrofuran용매

실험 절차

0.39 ml of morpholine and 0.05 g of tetrakis(triphenylphosphine)palladium(0) were added to a stirred solution of 0.15 g of methyl 3(R)-(allyloxycarbonyl)-2(S)-benzyloxy-5-methylhexanoate in 5 ml of tetrahydrofuran under a nitrogen atmosphere. After stirring the mixture for 0.5 hour the solvent was evaporated. The residue was dissolved in dichloromethane and washed in succession with 2M aqueous hydrochloric acid and water. The organic phase was dried over anhydrous magnesium sulphate and the solvent was evaporated. The residue was dissolved in diethyl ether and filtered. The diethyl ether solution was evaporated to give 0.16 g of methyl 3(R)-carboxy-2(S)-benzyloxy-5-methylhexanoate in the form of a yellow oil.

후처리

  1. customwas evaporated
  2. dissolutionThe residue was dissolved in dichloromethane
  3. washwashed in succession with 2M aqueous hydrochloric acid and water
  4. dry with materialThe organic phase was dried over anhydrous magnesium sulphate
  5. customthe solvent was evaporated
  6. dissolutionThe residue was dissolved in diethyl ether
  7. filtrationfiltered
  8. customThe diethyl ether solution was evaporated

출처 및 근거

ORD 기록
ord-9a48ea7c47b84e3ebdb4d2dc61f24d4d
출처 데이터셋
uspto-grants-2001_05
특허 번호
US06235787B1

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