Ammonia → 3-Methoxy-5-methylpyrazine-2-carboxamide

HRID 1978141노트

반응식

HRID 1978141 반응식
[CH3:1][O:2][C:3]1[C:4]([C:10]([O:12]C)=O)=[N:5][CH:6]=[C:7]([CH3:9])[N:8]=1.[NH3:14]>>[CH3:1][O:2][C:3]1[C:4]([C:10]([NH2:14])=[O:12])=[N:5][CH:6]=[C:7]([CH3:9])[N:8]=1

참가 물질

3

반응물 2

HCID 222AmmoniaHCID 21702987Methyl 3-methoxy-5-methylpyrazine-2-carboxylate

생성물 1

HCID 110627763-Methoxy-5-methylpyrazine-2-carboxamide수율 87%

실험 절차

1 g (5.5 mmol) of methyl 3-methoxy-5-methylpyrazine-carboxylate was initially charged in 15 ml (198 mmol) of NH3 (25%) and the mixture was stied at 50° C. After concentration, 0.8 g of 3-methoxy-5-methylpyrazine-2carboxamide was obtained. The yield was 86 percent. Other data concerning the title product was:

후처리

  1. customwas stied at 50° C
  2. concentrationAfter concentration

출처 및 근거

ORD 기록
ord-5ae1cef7b8154ee1815fb4d0c6ec7b33
출처 데이터셋
uspto-grants-2001_05
특허 번호
US06235905B1

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