1-Bromo-4-methoxy-2-methylbenzene → HCID 21996981, 화합물
반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:17][CH3:18])=[C:6]([CH:16]=1)[C:7]([C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][CH:10]=1)=[O:8].Br[C:20]1C=CC(OC)=CC=1C>>[Br:1][C:2]1[C:3]([CH3:20])=[CH:4][C:5]([O:17][CH3:18])=[C:6]([CH:16]=1)[C:7]([C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][CH:10]=1)=[O:8]참가 물질
3
실험 절차
Employing the same general procedure as for the preparation 5-bromo-2-methoxy-4′-methylbenzophenone (Compound H), 780 mg (3.9 mmol) of 4-bromo-1-methoxy-3-methylbenzene (Compound E) was converted into the title compound using 260 mg (1.9 mmol) of aluminum chloride, 0.6 mL (0.7 g, 4.7 mmol) of p-toluoyl chloride and 17 mL of dichloromethane. Purification by flash chromatography (silica, 5% ethyl acetate in hexane) gave the title compound as a white solid.
출처 및 근거
- ORD 기록
- ord-f07653caaca4497b9ac92301db52e1ef
- 출처 데이터셋
- uspto-grants-2001_05