HCID 21996975, 화합물 → HCID 21996970, 화합물
반응식
BrC1C=CC(O)=C(C=1)C(C1C=CC(C)=CC=1)=O.[Br:18][C:19]1[C:20]([CH3:36])=[CH:21][C:22]([O:34]C)=[C:23]([CH:33]=1)[C:24]([C:26]1[CH:31]=[CH:30][C:29]([CH3:32])=[CH:28][CH:27]=1)=[O:25]>>[Br:18][C:19]1[C:20]([CH3:36])=[CH:21][C:22]([OH:34])=[C:23]([CH:33]=1)[C:24]([C:26]1[CH:27]=[CH:28][C:29]([CH3:32])=[CH:30][CH:31]=1)=[O:25]참가 물질
3
실험 절차
Employing the same general procedure as for the 5-bromo-2-hydroxy-4′-methylbenzophenone (Compound K), 319 mg (1.0 mmol) of 5-bromo-2-methoxy-4-methyl-4′-methylbenzophenone (Compound I) was converted into the title compound using 2.4 mL (2.4 mmol) of boron tribromide (1M in dichloromethane) and 10 mL of dichloromethane. Purification by flash chromatography (silica, 10% ethyl acetate in hexane) gave the title compound as a pale yellow solid.
출처 및 근거
- ORD 기록
- ord-6de7745f09114e20bd712769e7e53a65
- 출처 데이터셋
- uspto-grants-2001_05