Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloride methanol → n-[1-(2-Phenoxyethan-1-yl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloride methanol | HCID 21893726 | — |
| 반응물 | N-[1-(2-phenoxyethan-1-yl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide | HCID 21993902 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | n-[1-(2-Phenoxyethan-1-yl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride | HCID 21993901 | — |
반응 단계
To a suspension of 414 mg (0.95 mM) of N-[1-(2-phenoxyethan-1-yl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide in ethanol (9 ml) was added 1.0 ml (4 mM) of 4N-HCl/methanol and the mixture was stirred at room temperature for 30 minutes. The resulting crystals were collected by filtration and rinsed with ethanol and ether to provide the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06235731B1 |
| 출처 데이터셋 | uspto-grants-2001_05 |
| ORD ID | ord-2ae5c4ed864d4d1690729d5a8fd1e0a6 |
| 출처 메모 | uspto-grants-2001_05 |