Water → HCID 178506300, 화합물

HRID 19785

반응식

HRID 19785 반응식
[F:1][C:2]([F:9])([F:8])[C:3]1[CH:7]=[CH:6][NH:5][N:4]=1.[Cl:10][O-].[Na+].O.C(=O)([O-])[O-].[Na+].[Na+]>C(O)(=O)C>[Cl:10][C:7]1[C:3]([C:2]([F:9])([F:8])[F:1])=[N:4][NH:5][CH:6]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 10340Sodium CarbonateHCID 18070343-(Trifluoromethyl)pyrazoleHCID 23665760Sodium Hypochlorite

생성물 1

HCID 178506300HCID 178506300, 화합물수율 77%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To a solution of 3-trifluoromethyl-1H-pyrazole (500 mg, 3.67 mmol) in glacial acetic acid (5 ml) was added a 10% solution of sodium hypochlorite in water (2188 μl, 3.67 mmol). The reaction mixture was stirred at RT overnight and then neutralized with sat. sodium carbonate, and extracted with DCM. The organic layers were combined washed with brine, dried (MgSO4), filtered and concentrated in vacuo to give the desired product (480 mg, 77%) as a white solid which did not require further purification. MS (ISP) 169.0 (M−H)−.

후처리

  1. extractionextracted with DCM
  2. washThe organic layers were combined washed with brine
  3. dry with materialdried (MgSO4)
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-64bade8d2a664b389339781759faacde
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745477B2

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